![]() ![]() In the NFG subgroup, there was no difference in the change in FPG or HOMA-IR between the two treatment arms. ![]() 0.34 mmol/l, respectively, P = 0.042) and a lower increase in HOMA-IR (0.05 vs. ![]() Among participants with IFG at baseline, those who took combined calcium–vitamin D supplements had a lower rise in FPG at 3 years compared with those on placebo (0.02 mmol/l vs. Therefore, we conducted analyses separately in participants with normal fasting glucose (NFG) (FPG <5.6 mmol/l, n = 222) and impaired fasting glucose (IFG) (FPG 5.6–6.9 mmol/l, n = 92) at baseline. RESULTS-The effects of combined calcium–vitamin D supplementation on 3-year change in FPG depended on baseline FPG ( P = 0.02 for interaction). In a post hoc analysis, fasting plasma glucose (FPG), insulin sensitivity (estimated by homeostasis model assessment of insulin resistance ), plasma C-reactive protein, and interleukin-6, were measured at baseline and 3 years. RESEARCH DESIGN AND METHODS-A total of 314 Caucasian adults without diabetes received either 500 mg calcium citrate and 700 IU vitamin D 3 or placebos daily for 3 years in a double-blind, randomized, controlled trial designed for bone-related outcomes. OBJECTIVE-We sought to compare the effects of combined calcium and vitamin D supplementation versus placebo on blood glucose and markers of inflammation in nondiabetic adults aged ≥65 years. ![]()
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